Expanding the World of Gluten Testing

Identify gluten reactivity with the comprehensive Array 3 from Cyrex Labs

A Better Diagnostic Tool

Minimize False Negatives
Test for multiple gluten proteins and peptides.
Understand the Triggers
Before you implement the treatment protocol.
Increase Compliance
Present patients with highly accurate and quantifiable test results.

What Doctors Are Saying About Array 3

"The Cyrex Array 3 offers the most comprehensive analysis available for determining gluten sensitivity. This array has proven incredibly valuable in my practice by providing in-depth information about an issue that has wide clinical implications."
David Perlmutter, MD, FACN, author of the national best seller Grain Brain
"My patients are complex, with a wide range of illnesses and symptoms. I use Array 3, the advanced test from Cyrex Labs, to test gluten sensitivity as I can confidently trust the lab results. My patients’ health and their life depend on accurate information. Both my patients and I are thankful for Array 3.”
Sharon Norling, MD, MBA,  author of Your Doctor is Wrong
"We run Array 3 on every functional medicine patient. We never run any other labs' gluten/wheat reactivity tests anymore because we believe that we get far too many false negatives. While other labs are running ab reactions on alpha gliadin only, Cyrex Array 3 shows the reactions to several gliadins and other wheat proteins. Close to 50% of the Array 3 tests come back negative for alpha gliadin, but highly positive for the others. Running the transglutaminases also helps patients see what tissue groups may be affected by these inflammatory reactions, which helps drive home the importance, if gluten reactive, of staying away from gluten for life. Great for compliance!"
—Stephanie J. Chaney, DC & Thomas A. Chaney, DC, authors of Lose the GLUTEN, Lose Your GUT. Ditch The GRAIN, Save your BRAIN.

Recommended for Patients Who

Have non-responsive GI symptoms
Present multiple symptom complaints (including Chronic Fatigue Syndrome and Fibromyalgia)
Suffer from depression or neuro-autoimmunity

Array 3 - Wheat/Gluten Proteome Reactivity & Autoimmunity™

Illustration dramatized for visual purposes. © 2012-2013 Cyrex Laboratories, LLC. All rights reserved.

Antigens Tested

  • Wheat IgG
  • Wheat IgA
  • Wheat Germ Agglutinin IgG
  • Wheat Germ Agglutinin IgA
  • Native + Deamidated Alpha-Gliadin-33-mer IgG
  • Native + Deamidated Alpha-Gliadin-33-mer IgA
  • Alpha-Gliadin-17-mer IgG
  • Alpha-Gliadin-17-mer IgA
  • Gamma-Gliadin-15-mer IgG
  • Gamma-Gliadin-15-mer IgA
  • Omega-Gliadin-17-mer IgG
  • Omega-Gliadin-17-mer IgA
  • Glutenin-21-mer IgG
  • Glutenin-21-mer IgA
  • Gluteomorphin+Prodynorphin IgG
  • Gluteomorphin+Prodynorphin IgA
  • Gliadin-Transglutaminase Complex IgG
  • Gliadin-Transglutaminase Complex IgA
  • Transglutaminase-2 IgG
  • Transglutaminase-2 IgA
  • Transglutaminase-3 IgG
  • Transglutaminase-3 IgA
  • Transglutaminase-6 IgG
  • Transglutaminase-6 IgA
Array 3 requires 2 mL of serum

How To Order Array 3

To order Array 3, you must be a licensed healthcare professional.

Frequently Asked Questions

Below are answers to some common questions about Array 3 - Wheat/Gluten Proteome Reactivity & Autoimmunity™ from Cyrex Labs.

Can a person test positive against one of the components of wheat but be negative for a response to the whole kernel of wheat?

Yes. Wheat is made up of many proteins and peptides. The immune response to the whole kernel may be limited, even if a patient is very reactive to the smaller proteins and peptides, such as glutenin or gluteomorphin.

Are there any medications, foods, conditions, or other factors that could interfere with the results of a Cyrex Labs test?

Yes. While Cyrex Labs is unable to provide an exhaustive answer to this question due to the interactive complexities and varieties of medications and patient circumstances, the following has been noted:
a. Immunosuppressant and corticosteroid drugs can reduce antibody production and cause false negative results.
b. Limited assessments on the effects of aspirin, acetaminophen, and antipsychotics on Arrays 1-4 have been performed. No noticeable effects were observed.
c. Unknown cross-reactive epitopes from foods and microorganisms may stimulate the antibody production in the absence of a true antigen. Cyrex Labs has already developed Array 4 in order to recognize the most common antigens in this regard.
d. A gluten-free diet can cause false negative results on gluten protein/peptide tests.
e. Certain conditions, such as ileal pouch surgery, may cause a false positive celiac serology.1
1. Lian L, Remzi FH, Kiran RP, Fazio VW, Shen B. Clinical implication of false-positive celiac serology in patients with ileal pouch. Dis Colon Rectum. 2010 Oct; 53(10):1446-1451.

Why should I use Cyrex Labs rather than another lab?

Researchers have proven that 50% of patients diagnosed with Celiac disease do not respond to the one protein being assessed in the conventional tests, instead they react to one or more of the other gluten proteins that are not measured in those conventional tests.  Additionally, more labs are switching to only offering deamidated gliadin because it is more sensitive for Celiac disease.  Unfortunately, the larger percentage of the population, Non-Celiac Gluten Sensitive patients, has been shown to be more reactive to native gliadin.  At Cyrex Labs we measure both native and deamidated gliadin along with other gluten family proteins, the opioid peptides from both gluten and wheat, the lectin portion of wheat and wheat as a whole.  Because not every person’s gluten reactivity manifests as Celiac disease, Cyrex Labs measures antibodies to multiple transglutaminases to capture those patients whose gluten reactivity manifests as skin disorders or neurological complaints.

Let's Get Started!

To order Array 3, you must be a licensed healthcare professional.